Biofilm Prevention – Preempt Infection

Up to 80% of human infections are associated with biofilm, a microbial community embedded in a self-produced, glue-like matrix that can form on any surface. Bacteria in biofilm are 500 – 5000 times more resistant to disinfectants, antibiotics and to our immune system.

Nobio® developed game-changing technology with the goal to prevent medical device contamination indefinitely, as the first and only fully-integrated anti-biofilm solution. The technology core consists of extremely potent particles which are covered with a high concentration of highly-active anti-microbial structures that kill bacteria upon contact. The Nobio® particles can be permanently embedded in many products and materials to inhibit formation of biofilm, indefinitely.

Nobio® Technology – The Optimal Protection

Superior Anti-Microbial Activity

Superior anti-microbial activity

More than 6 Log reductions (106) in bacterial count

Acts indefinitely

Acts indefinitely

Nobio® particles bind irreversibly to the material and do not lose activity over time

Non-toxic

Non-toxic

Do not contain metals or other toxic materials

Durable

Durable

Unlike coating, Nobio® particles are embedded within the material and will not leach out

Broadly effective

Broadly effective

Tested and found effective against all common pathogens including multi-drug resistant bacteria (“superbugs”)

Strong, Long Lasting Performance

Nobio’s technology resulted from a decade of focused, multidisciplinary research and has been extensively studied.
Download PDF for a list of selected publications.

More than 6 Log Reductions (>106) of Bacteria After 6-Month Aging

Samples (8 per group) with 1% Nobio particles were aged for 6 months in simulated indwelling conditions (physiologic solution replaced every 48 hrs, and then inoculated by >1,000,000 (106) bacteria per 1µl and cultured for 24hrs. Maximal bacteria growth was observed on samples with no particles or bacteria alone, while no bacteria grew on the samples with 1% Nobio particles.

Quint Int (2010) 41(10),827-835

performance

Scanning Electron Microscopy

Images of scanning electron microscopy (x4000) of bacteria (S. mutans) in
direct contact with material, with and without Nobio® particles (1%)

Scanning Electronic Microscope
Scanning Electronic Microscope

Human Studies

Human Studies

In this split mouth clinical study, disks made from dental composite material with 1% Nobio® particles and without particles were placed in the mouth of 10 healthy volunteers for 4 hours. Examination with confocal laser scanning microscopy showed mostly dead bacteria on the 1% Nobio® samples vs. mostly live bacterial on the untreated, control samples.

Polyethyleneimine nanoparticles incorporated into resin composite cause cell death and trigger biofilm stress
N. Beyth, I. Yudovin-Farberb, M. Perez-Davidia, A. J. Dombb, and E. I. Weiss, P N A S 2010 21: 107(51): 22038-43