Unlike any other antimicrobial technology
Nobio’s breakthrough technology uniquely combines strength, longevity and safety. When encountering bacteria or virus, the Nobio particles exert strong, concentrated electrostatic stress, causing their breakdown and death. The particles are non-soluble and their mode of action does not require any chemical release or exchange, so they remain active indefinitely, without affecting the surroundings.
The novel particles consist of a solid core and a high concentration of covalently-bound functional molecules, which multiplies the antimicrobial effect. The solid core enables to permanently embed the particles in the bulk of the treated material, or anchor it to its surface, to provide strong and long-lasting protection.
Scanning Electron Microscopy
Images of scanning electron microscopy (x4000) of bacteria (S. mutans) in
direct contact with material, with and without Nobio® particles (1%)
Nobio™ Technology – Optimal Protection
SUPERIOR
ANTIMICROBIAL ACTIVITY
Nobio® particles are covered by high concentration of covelantly-bound functional groups that compound the antimicrobial effect
LONG
LASTING
Nobio® particles are non-soluble and permanently embdded so they do not lose activity over time
BROADLY
EFFECTIVE
Tested and found effective against many common pathogens including multi-drug resistant bacteria (“superbugs”)
DURABLE
Nobio® particles are embedded within the material and will not leach out
SAFE
Do not contain metals
or other toxic materials
Strong, Long Lasting Performance
Nobio’s technology resulted from a decade of focused, multidisciplinary research and has been extensively studied.
Download PDF for a list of selected publications.
More than 6 Log Reductions (>106) of Bacteria After 6-Month Aging
Samples (8 per group) with 1% Nobio particles were aged for 6 months in simulated indwelling conditions (physiologic solution replaced every 48 hrs, and then inoculated by >1,000,000 (106) bacteria per 1µl and cultured for 24hrs. Maximal bacteria growth was observed on samples with no particles or bacteria alone, while no bacteria grew on the samples with 1% Nobio particles.
Quint Int (2010) 41(10),827-835
Human Studies
Anti-biofilm Effect Invivo
In this clinical study, disks made from dental composite material with 1% Nobio™ particles and without particles wereplaced in the mouth of 10 healthy volunteers for 4 hours. Examination with confocal laser scanning microscopy showed mostly dead bacteria on the 1% Nobio™ samples vs. mostly live bacterial on the untreated, control samples.
Polyethyleneimine sub-micron-sized particles incorporated into resin composite cause cell death & trigger biofilm stress N. Beyth, I. Yudovin-Farberb, M. Perez-Davidia, A. J. Dombb, and E. I. Weiss, P N A S 2010 21: 107(51): 22038-43
Antibacterial Wound Dressing
In this clinical study, disks made from dental composite material with 1% Nobio™ particles and without particles wereplaced in the mouth of 10 healthy volunteers for 4 hours. Examination with confocal laser scanning microscopy showed mostly dead bacteria on the 1% Nobio™ samples vs. mostly live bacterial on the untreated, control samples.
Polyethyleneimine sub-micron-sized particles incorporated into resin composite cause cell death & trigger biofilm stress N. Beyth, I. Yudovin-Farberb, M. Perez-Davidia, A. J. Dombb, and E. I. Weiss, P N A S 2010 21: 107(51): 22038-43
Atar-Froyman L, Sharon A, Weiss EI, Houri-Haddad Y, Kesler-Shvero D, Domb AJ, Pilo R, Beyth N, Anti-biofilm properties of wound dressing incorporating nonrelease polycationic antimicrobials, Biomaterials 46 (2015) 141-148.
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