Biofilm Prevention – Preempt Infection
Up to 80% of human infections are associated with biofilm, a microbial community embedded in a self-produced, glue-like matrix that can form on any surface. Bacteria in biofilm are 500 – 5000 times more resistant to disinfectants, antibiotics and to our immune system.
NobioTM developed game-changing technology with the goal to prevent medical device contamination indefinitely, as the first and only fully-integrated anti-biofilm solution. The technology core consists of extremely potent particles which are covered with a high concentration of highly-active anti-microbial structures that kill bacteria upon contact. The NobioTM particles can be permanently embedded in many products and materials to inhibit formation of biofilm, indefinitely.
Nobio™ Technology – The Optimal Protection
Superior anti-microbial activity
More than 6 Log reductions (106) in bacterial count
NobioTM particles bind irreversibly to the material and do not lose activity over time
Do not contain metals or other toxic materials
Unlike coating, NobioTM particles are embedded within the material and will not leach out
Tested and found effective against all common pathogens including multi-drug resistant bacteria (“superbugs”)
More than 6 Log Reductions (>106) of Bacteria After 6-Month Aging
Samples (8 per group) with 1% Nobio particles were aged for 6 months in simulated indwelling conditions (physiologic solution replaced every 48 hrs, and then inoculated by >1,000,000 (106) bacteria per 1µl and cultured for 24hrs. Maximal bacteria growth was observed on samples with no particles or bacteria alone, while no bacteria grew on the samples with 1% Nobio particles.
Quint Int (2010) 41(10),827-835
Scanning Electron Microscopy
Images of scanning electron microscopy (x4000) of bacteria (S. mutans) in
direct contact with material, with and without Nobio™ particles (1%)
In this split mouth clinical study, disks made from dental composite material with 1% Nobio™ particles and without particles were placed in the mouth of 10 healthy volunteers for 4 hours. Examination with confocal laser scanning microscopy showed mostly dead bacteria on the 1% Nobio™ samples vs. mostly live bacterial on the untreated, control samples.
Polyethyleneimine nanoparticles incorporated into resin composite cause cell death and trigger biofilm stress
N. Beyth, I. Yudovin-Farberb, M. Perez-Davidia, A. J. Dombb, and E. I. Weiss, P N A S 2010 21: 107(51): 22038-43